The only reason they want to use a tool that doesn't really fit their use case, is because they're not aware of better tools. I find it very hard to believe that scientists actually want to use a tool that corrupts their data. If that is true, then that is absolutely a problem with their attitude towards science and data.
It's not that hard to imagine a tool that can do exactly what Excel can, but without corrupting your data. It might even exist already. LibreOffice got mentioned a lot; it can do almost(?) everything Excel can, but without corrupting your data. If there are problems with it that make it useless to scientists, there's a good chance the LibreOffice community can fix them.
I think better tools that preserve the integrity of their data are absolutely the solution here.