It does because these Uyghurs are subjected to hard labor where they’re producing goods for Nike, Gap, H&M, Amazon, Puma, etc. It’s a lot harder to look past these things when you know they’re happening (similarly to how it’s hard for football fans to look past the slave labor used for the World Cup in Qatar). The fact that their treatment feels equivalent to the holocaust makes it even worse.
It also adds great frustration/anger when western companies fight for human rights in USA while they stay silent on China’s human rights issues (and even censor western citizens voicing support for them).