* The underlying code is relying on x86 features or is x86 ASM. In that case ya... this is going to be a bit rough - but is a super minority, especially for use cases where you'd want to use ARM
* The runtime or compiler hasn't been ported to ARM yet. For compilers, I don't think this is a problem - I think both clang and gcc are completely ready to go for armv7 and arm64. Go is good to go too. Runtimes is a bit more dodgy, but all the major (Java, C#, Python, Ruby, Perl, Javascript/Node) languages and runtimes are just fine. Maybe the only one out is rust, which doesn't have ARM as Tier 1 supported (but should just work) yet.
* Hardware support. There may not be good open source drivers for various ARM specific hardware blobs.
What else were you thinking of?