The removal of the physical page turning button rendered one handed usage impossible if you want hold the kindle in your left hand. It is massively annoys me.
You only need to be able to reach about a 1/3 of the way over the screen to tap the part that changes to the next page. Takes a little time to get used to but I read left handed all the time.
Instead of tapping the left of the screen swipe from right to left and it’ll go to the next page. The UX on that is awful as it’s never mentioned, but it is very possible to read left handed.
How small are your hands? Thumb on one side, pinky/ring on the other.