For my own story, my work, location and daily activities were not aligned with the life I wanted to live and weren't ever going to get me closer to what I wanted. I'd spent my 20's figuring out how to fit in, be likable, be a good employee. But the American dream is quite dead for most people and it was dead for me. Following the crowd was never going to even get me a white picket fence in my city, even if I'd wanted one.
The result has been the 6 most fantastically awesome years of my life. It's taken me to a new career, new locations, and new ways of doing everything. If you've read 4 hour work week, you'll know that Ferriss had years of adventures that most will never experience. It's been like that, but better.
If this is speaking to you. DO IT.