Looking into this, it needs a simple control system. The PU-238 bricks just made heat continuously with no control. But, they were also much less power.
If there's a control system you can launch the reactor cold. With the Plutonium bricks you cannot, meaning your cooling system (engine in this case) has to keep running during launch.
https://ntrs.nasa.gov/archive/nasa/casi.ntrs.nasa.gov/200900...
I don't think there was any way to save and restart anything if an engine failed as it would have likely destroyed the engine.
https://rps.nasa.gov/system/downloadable_items/36_APP_ASRG_F...
(2) Cooling. Space is hot. (+400c)
(3) Running the computer.
(4) Running the communications gear.
(5) Cooling 4+5.
https://en.wikipedia.org/wiki/External_Active_Thermal_Contro...
Nobody knows what kind of innovations a huge readily available sustainable energy supply would allow, but I bet they'd be cool.