We've all accidentally left the soldering iron on, sometime in our decades. The sensors in the iron lets it shut off and not burn your house down. Having an firmware (like the TS100 or TS80) means you can fully customize its behavior unlike most consumer devices. (I wish there was a microwave oven whos firmware I could tweak in order for, eg the popcorn button to make popcorn how I like my popcorn.)
Soldering irons are at this fairly unique intersection of consumer device and hardware hacker that I'm really surprised by the some of the luddite attitudes around here. I bet there's some cool firmware mods you could do if you have to solder something that looks like a heat sink. (Eg maybe it could do 18650 cells, if you don't have a welder.)
The other innovation of the TS100 is that battery-power capably powers a soldering iron. The TS100 is a bit older than the TS80, and can use 12V rechargable battery packs (eg for RC cars/planes); the TS80P can use recent USB-battery pack powering standards. It doesn't do much at the workbench, but if you're one of those people that leaves the house (modulo Covid), it turns out to be really useful! In decades prior, butane (cigarette lighter fluid) powered soldering irons existed, but could be persnickety and were a special version to buy. Now, just bring the iron along with USB battery pack you were probably gonna bring anyway.