Most things that climate change deniers post are factually accurate. If you would target the basis of their claim with the data they provide, you will always lose. Being a climate change denier when you only have access to facts that don't support climate change is only logical.
To disprove them requires you to have even greater subject matter knowledge than they do, which is unfeasible for most normal people. Even at a top university you would need several years to become a subject matter expert. Clearly not a feasible strategy for every commenter on HN.
So what can we do? Most "Climate Skeptics Science", while not being factually disproven, can lose a great amount of credibility by background checking things like authors, what scientific conferences or journal a paper has been submitted to, if it is peer reviewed, etc. In fact, with enough loss of credibility it becomes the burden of the author to prove that they/their paper is credible (see what I did there?).
If there was a clear bias in the authors' background, this would call into question the credibility of the paper. Humans are well-equipped to understand bias without a university degree, less so with bioengineering.
To summarize: HN commenters are generally ill-equipped to prove/disprove arguments in a scientific paper. Like in most sciences this isn't always necessary since you can put the credibility of the authors up for test. If they fail that test, they must prove their credibility before their scientific argument carries any weight. Most HN-commenters are adept at judging other peoples biases.