Yeah, I think a service like this might be very useful for quick prototyping and proving out an MVP thanks to the native es6 modules, but I personally wouldn't rely on it for anything critical.
Coincidentally jspm.dev, a similar ES modules CDN in this space recently released a new version as well: https://jspm.org/jspm-dev-release
Their release post had a lot more technical details (including their strategy for code splitting which is critical for the production use case) so I'm inclined to trust them a little bit more for production use cases. Curious where I could read more about the architecture behind Skypack?