It's definitely going to take some work. I have set up my first NixOS install, and the functionality is very impressive, but usability-wise it is a mess.

I think Nix/Guix is going to be the bridge to the post-POSIX world where we can move away from the trend of a globally visible filesystem and into much stronger container-based approach. But it can't be in its current form; the Nix language and Guix's Guile/Scheme are too difficult and not declarative enough.