I've been using UASP SSD drives in Linux for ~ 5 years, the main issue I face is not performance related but w.r.t monitoring.
S.M.A.R.T doesn't behave well with UASP, so not all Smartmontools's feature work[1]. Especially, LifeTime of the SSD don't and they are crucial. I had to resort to calculating remaining life of the SSD manually from the reported lifecycles and negating it with the manufacture's MTBF if they're reported.
I've faced this with devices from varying price range [USB 3.0/3.1] - MyDigitalSSD(OTG), Samsung T5, various ORICO USB SSD enclosures with Samsung EVO/Crucial SSDs on host systems of different architectures(x86/ARM).
How are you all monitoring the life of your USB SSD on UASP in Linux?