There is nothing in the Node ecosystem to replace Django’s ORM, migrations, or admin.

In my startup, I’m using a typescript/node backend to serve graphql, while still using Django for migrations and the admin. It’s a bit odd but works fine.

If you’re starting a new project, I’d strongly consider using Django for the whole backend, with graphene for graphql, and create-react-app on the frontend. Apollo’s type generation is a big help in keeping the two parts synced.