I wouldn't cast it quite so simply. Smith and the classical liberal tradition he represented would likely be skeptical of regulations by default, but would evaluate them based on costs and benefits.
You make an excellent point about Smith's treatment of firms as local artisans rather than large corporations. Incidentally, he uses the word corporation a paragraph below what I pasted, but it most likely refers to guilds or firms with monopolies, and not our modern idea of corporate bodies.
That said, I tend to think of Coase as the sort of successor to Adam Smith's thinking. I find it not coincidental that Coase formulated the modern theory of the firm that economics still subscribes to, as well as extrapolating transaction costs into the realms of legal disputes and the administrative state. Coase himself was also skeptical of government regulation, not as a matter of ideology or principle (in fact, he said that in principle, many regulations could be effective, though he did also argue reductio ad absurdum that the state should regulate speech as vigorously as products [0]), but as a matter of empirical investigation [1].
[0] https://web.ntpu.edu.tw/~guan/courses/Coase74.pdf
[1] https://reason.com/1997/01/01/looking-for-results/