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In addition to being easier to install, Redshift has the benefit of working properly in multi-monitor environments.

$0.02

I have f.lux in two monitors, with no problems. Windows 7 64 bits.

Should have clarified: In Linux, f.lux does not appear to work with multiple monitors. Redshift works great in Linux.

FWIW, f.lux is working fine on Ubuntu 10.04, with multiple monitors, for me.