Python? That doesn't make sense. Anyone who appreciates Perl would surely choose Ruby over Python.
Although I suppose the way things are headed in a few years that might become... JavaScript, of all things. The theory that the world truly ended in 2012 becomes more appealing every day.
As far as I know, it's still the best option there is for quickly building a MVP on the web if one isn't building a SPA.
If you had told me 5 years ago that I'd be recommending PHP as an alternative vs. RoR I wouldn't have believed you, but the PHP world has improved in ways that I wouldn't have thought possible.
Also, there is Crystal, for compiling something very similar to Ruby, to native.