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What was wrong with Niacin? 1500mg of Niacin stops it in less than 20 minutes for me.

Yeah, FWIW, R. A. Wilson talks about how B3 was known anecdotally back in the 70's in "Sex and Drugs" as good for bad trips.

It seems odd (in a funny manner) that you'd need 1500mg of something to counter the micrograms of the thing you previously took.

I think this is pretty normal in biology. Like how someone might have to drink 2L of water to feelbetter after a few shots of alcohol