Using mixed-blurriness environment sounds like a nightmare to me, even if everything should work correctly.
I work every day with a 4K monitor and a 1080p monitor side-by-side and it works well. Linux couldn't handle it in any configuration, especially with mixed Intel integrated+nvidia graphics, but Windows is a champ.
Obviously it's not so great with Xwayland, definite blurriness there. But to compare, the only workable X11 setup was one that ignored my 4K screen entirely and the whole thing was blurry.