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I don't know, are go-to statements and code reuse a small twist in the dogma of software engineering?

Is your Python-level code directly interacting with CPU operations and memory bit flipping a small twist?

Hi-C 3D DNA structure experiments as well as small RNA fragments interfering with transcriptions and protein function are not a small twist in my opinion - it's like finding out there's an entire extra hierarchy of layers to the system.

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Those are great and non-obvious discoveries, but they don't particularly change the fact that (virtually?) all genetic information is carried via DNA. (...and possibly similar mechanisms that don't particular change the overall story)

Well, no, it doesn't change the fact that DNA contains (most of) the information. What it means is that even if I give you all of the bases on all of the chromosomes, if you don't know how these strings of beads will fold in a real cell (in the presence of all kinds of other things, like proteins and metal ions, which in a fertilized egg will come from the mother - a bootstrapping problem), it does not get you very far. It might not be unlike getting all the lines of code in a codebase, but not getting the ordering, only a bag of lines of code.

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