The rub that ad-advocates never seem to mention : ad-affiliate networks really don't give a shit about your readership, and they'll 1) readily serve your readers malware, while 2) avoiding blame or investigation once they do -- and this isn't even mentioning the tracking and privacy concerns one might have with enabling ads within unstable or destabilizing world states.
At one point a few years ago it was said that something like 10-20 percent of unauthorized MMORPG logins was due to targeted malware being spread among fan sites via ad-affiliate networks using key-words and targeted market/interest features.
Provide alternative ways for me to give you my money, if you think I (the reader) gain value from the service.
Advocating for someone to turn off an ad-blocker nowadays is sort of akin to game-developers telling purchasers to disable their firewall to play online. Yeah, that's a solution, but it leads to numerous other issues, and is hugely irresponsible on the part of the developer.
Trusting a third party to serve me relevant and safe ads is a pipe-dream that has yet to come into reality.