Two years ago Microsoft released an update that killed Windows on my brand new (at the time) desktop (i7-8700k, gtx 1080). I thought "no big deal, I'll boot up my old desktop and deal with it later" but when I turned on that machine (i5-2500k, rx480), it applied the same update and also killed the Windows install. At that point I gave up on using a desktop for the day and booted up Windows on my laptop (i7-7700HQ, gtx 1050m), only to have that also install the update and kill the install.
I'd had Windows updates break before that, but always on one machine so it was easy to write off as some driver quirk or something weird I had installed.