I feel like maybe I misread your post. Perhaps I didn't understand the larger point you were making.
> Now it is largely acceptable, to permanently disable or kill someone due to a mistake or some form of common negligence while operating a vehicle.
There were many years at the beginning of the automobile where laws were created[1] to save humans, horses, and livestock from being run into by automobiles or locomotives. After enough of society was normalized to the existence of large guided missiles, these ways were dismantled.
> It is almost not a crime to accidentally run someone over. This is “normal” or “not intentional.”
It's not 1st degree murder (usually), but the circumstances of a traffic collision do sometimes bring felony convictions. Society has absorbed the risk and people have adapted.
Interesting note: US and Euro cars can't be homogenized because the US NHTSA tends to assume that passengers don't wear seatbelts (so manufacturers optimize for fewer injuries with that assumption) whereas the Euro equivalent assumes that all passengers do wear seat belts and optimize for that assumption.
> In the future, it will seem insane to have allowed so many people manual control over multi-ton vehicles.
I think future people will be capable of some amount of empathy with people who came before them who had to deal with inferior technology.
[1] https://en.wikipedia.org/wiki/Red_flag_traffic_laws