This.
I had the same realization maybe 7 or 8 years ago and it is true for me. With multiple monitors it's like moving your hands away from the keyboard all the time and looking for the mouse. Same happens for me while looking for anything across the 2 or 3 monitor setup. It just weakens your focus... If I'm on a laptop (and I usually am), I just use the laptop's screen. Getting used to a different screen size while working with my laptop setup would also slightly slow me down when I'm bound to use only the laptop.