The historical timeline is especially interesting because Reddit's cofounders Steve Huffman & Aaron Swartz were alumni of Paul Graham's first YC batch and PG is the author of the well-known Lisp essay "Beating the Averages":
- 2001-04 Paul Graham : Lisp essay "Beating the Averages" [1]
- 2005-07-26 Paul Graham : https://groups.google.com/forum/#!topic/comp.lang.lisp/vJmLV...
- 2005-12-05 Steve Huffman : https://redditblog.com/2005/12/05/on-lisp/
- 2005-12-06 Aaron Schwartz : http://www.aaronsw.com/weblog/rewritingreddit
The takeaway from the Reddit case study is this: Yes Lisp macros and language malleability gives it superpowers that other languages don't have (the "Blub Paradox") -- but other languages also have other superpowers (ecosystem/libraries) that can cancel out the power of Lisp macros.
You have to analyze your personal project to predict if the ecosystem matters more than Lisp's elegant syntax powers.