Jitsi is a full application (web app, backend servers) with a specific use case: meetings (similar to Zoom or Google Meet).

mediasouop is not an application but a set of server and client low level libraries to build whichever kind of audio/video applications (not just meetings). You don't "install mediasoup and configure it". You create your Node app and integrate mediasoup as you do with any other NPM dependency. Same in client side. More here:

https://mediasoup.org/documentation/overview/

Of course, this means that you must build your application, including UI, client-server signaling, etc etc.