No thanks, my "This Site Under Construction" pixel art would look awful as a video. And last I checked, video didn't even support transparency!
The main problem I've been encountering is that everything seems to be based on YUV, which makes it difficult to round-trip RGB data without loss.
I started looking for lossless because my screen captures looked like absolute garbage even at high bit rates, but in retrospect, I bet the problem was the downscaling done by the 4:2:0 chroma profile. It might be that 4:4:4 would fix the awful appearance.