There are so many positions at Microsoft, for example, that I would have loved to apply for, but they require you to be in Redmond, and I'm just not in a position to relocate.
I started working in one team and switched to another team internally because they are pro-remote and I plan on moving back to Australia. Broadly across Microsoft there are also about ~30 other engineers already working from Australia for Redmond-based teams.
I don't know about Microsoft in particular, but from what I've seen it's much easier to find a remote position while you're already at a company working onsite than it is before you get hired.