I read up on this because I had a really bad sinus infection a couple months ago and found myself taking "Emergen-C" every morning, which advertises "1000% your daily value of Vitamin C". Immediately after my sinus infection cleared up the virus stuff started, so I kept taking it for a while.
From what I read, at least with Vitamin C, you have to get into the 2000% range before there start being negative side-effects.