A few weeks ago I tried Tabletop Simulator with two other friends to play Gloomhaven[+]. I admire the developers that took on such a (positively) complex and rich game as Gloomhaven.
But it was a far cry from in-person playing (I realize). It's very much understandable—you just can't replicate that high-definition feeling you get from in-person game, especially from such a rich game. I was 'dejected' (again, that's not the right word) enough that I didn't try Tabletop Simulator anymore. Maybe I should try other games.
Man ... do I now wish that I hadn't turned down (with lazy excuses) all those in-person Gloomhaven sessions I was invited to.
Live and learn.