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Comment by danieltillett | Hacker News Reader

Yes. What we really want is a strain that has infected a whole lot of people and all of them have had a mild case.

>What we really want is a strain that has infected a whole lot of people and all of them have had a mild case

How about 10 to 50 million ?

I live in Nigeria. Between December and late February, many people in Nigeria and Ghana report experiencing symptoms similar to those that could be caused moderate COVID-19 infection. These included, fever, diarhoea, cough, sore throat, malaise.

Many physicians and scientists I know think it we may have had a mild outbreak of the disease. If so, was this reduced severity due to a mild strain of the virus or to other factors ? It warrants investigation. Your proposal and the theory underlying it make a lot of sense.

I would really like to be able to dig deeper into this.

That is also the symptoms of the ordinary flu which is the more likely candidate.

Lassa fever also occurs often in Nigeria

What's the relationship between Lassa fever and covid-19 ?

People get a fever, and think it is covid, but it is actually lassa

Look up the symptoms of lassa fever. It could not possibly be confused for anything else. Besides, it occurs in specific locales.

>In 80% of those who are infected little or no symptoms occur. These mild symptoms may include fever, tiredness, weakness, and headache.

Those are also covid symptoms

The median age in Nigeria is 18.4 years, while in Italy it's 45.5 years.

Nigeria might have more immunocompromised people due to AIDS. But is there any reliable accounting of deaths, much less the reason?

In any case, I wouldn't be surprised if age and lack of accounting is why you don't see a problem in Nigeria.

Source: https://en.m.wikipedia.org/wiki/List_of_countries_by_median_...

1. Age is not the main factor at play here. While the median age is lower than Italy's there are still a lot of elderly people in Nigeria. On an age and population adjusted basis, Nigeria has nowhere near the number of cases and deaths as Italy.

2. The demographic profile and phylogenetic makeup of Nigeria is similar to Cameroon which has experienced more cases and deaths than Nigeria in both absolute numbers and on a pro-rata basis. This makes some of us believe we are dealing with two different circulating strains in both countries.

3. It definitely is the case that testing is not adequate but a highly susceptible affected population would soon be revealed by the number of symptomatic cases and, (more to the point), deaths. Both indices have remained relatively low

If you are part of a cluster of a viral infection and you suspect Covid, then look for Anosmia as a symptom.

Anosmia is reported in 30%+ of Covid cases. Flu/cold viruses can cause Anosmia but it obviously isn’t common since you don’t hear about it and it isn’t given in lists expected symptoms.

Within a sample of 10 people that have Covid, you have an expected number of people that would have Anosmia.

https://www1.racgp.org.au/newsgp/clinical/push-to-include-an...

Beware of false information https://www.nationalgeographic.com/science/2020/04/lost-your... because AFAIK the journalist has incorrect thinking: “flus and colds are a common cause of Anosmia” DOESN’T mean that “Anosmia is a common symptom” (the abstract they reference is poorly written, still poor journalism IMHO).

I would appreciate any references to data showing how uncommon Anosmia is in cold/flu patients (I did look, but didn’t look hard).

You probably won't find that... You might find a strain where 99.9% of people get a mild case.

Who is going to be the person to recommend deliberately spreading that strain to the world population, knowing that 0.1% of the world, 7 million people, will end up in a hospital and die?

Sure, overall, fewer people might die, but the reality is whichever world leader makes that call has effectively just signed a death warrant for 7 million people. That isn't the way to get re-elected.

I think we can do better than 0.1% death rate. In principle there is no reason we can’t find a strain that is no more dangerous than the coronaviruses that cause the common cold.

One thing is certain and that is unless we go out and look we won’t find anything.

@danieltillett

I could quickly put together a team focused on southern Nigeria and Ghana to find through word of mouth, medical records, contact tracing lists and social media, people who have experienced covid-19 symptoms and are likely to have had the disease. My team would also collect samples from people in the worst affected areas who are asymptomatic. In this way, we could collect data and enough samples to isolate a(?the) virus if any.

Do you know any organisations that could provide funding and support for this ?

It is probably best to contact me offline. My email details are on my website.

0.1% would be great. That's the mortality of the regular flu and we have ramped up the hospitals to cope already so the 0.1% severe cases would be better handled. That would be much better than we manage the flu. It would also make it actually possible to take risk groups and isolate only those for a longer time without crashing the economy. It would be the opposite of the flu where vaccination is focused on risk groups.

You would infect on purpose the 80% of the less vulnerable population for herd immunity

Agreed. But for the heard immunity one does not have to go and vaccinate/expose to an attenuated strain of virus the whole population. Even getting a majority of say under 50yo immunized should have a big effect.

These are special times. In reality it does not matter if this 0.1% +70yo will die after vaccination since the mortality rates in this age group infected with the wild type are bigger by about two orders of magnitude. But out of concern to human rights it will make sense not only to exclude any immunocompromised people but also make it voluntary to the groups where mortality rates are at certain level.

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