You are probably thinking of galaxy rotation curves which do not agree with theoretical predictions that assume only visible matter exists.

Gravity not following the ISL at large scales would indeed be a possible explanation for this. However, most alternative theories of gravity clash with other observations, such as the motion of binary pulsars or gravitational waves, whereas (unmodified) General Relativity is in excellent agreement. This is one of the reasons why the existence of dark matter is considered to be a much better explanation for the deviation of the rotation curves.