If you're doing this in your kitchen, stay far, far away from lead.
If you're doing this in your commercial building's electronics lab, where food and drink is prohibited, and there are only electronics people around... leaded solder is going to win.
If you're doing this in your factory, where your processes are tightly dialed in and you're moving mountains of product... now you can use either one just as easily, so there's no reason to risk lead unless the customer or application demands it.