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Is there a way to have some more fine-grained control about how Rosetta and Folding use resources? For example, I want them not to run in sleep mode, and certainly not when the laptop's lid is closed. Or, better perhaps, to throttle above certain temperatures.

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Yes, those knobs can be controlled by the BOINC client. You retain full control over how/when your computer uses its resources.

It's very configurable. I let BOINC go to town for up to an hour whenever I leave my computer alone, then the computer can go to sleep. It's not running continuously but the progress adds up steadily over time.

Where exactly? I haven't been able to find it.

Oh, I see: Options / Computing Preferences.

Would still like to have a "suspend when lid is closed" or "suspend when temperature is > 70°C" option, but I guess that would require a lot more hardware specialization than the authors of the tool could reasonably be expected to do.

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