>Nobody is really running an RNA sequencing experiment to evaluate the impacts of a drug on the rna transcriptome with falsification in mind (even if in a sense the null of "nothing changes" is what you're trying to falsify"). Psychologically it's just seen as some exploration to see what happens.

Isn't this, along with and maybe encouraging p-hacking, a major cause of the non-reproducability crisis? Scientists hunting out supporting evidence instead of showing their theories don't easily break?