An application written with original logic directly to the requirements provided will be smaller, execute faster, and require less overhead to maintain than something written with a giant framework provided your developers know what they are doing. One of the biggest selling points to using a large framework is precisely because many developers don't know what they are doing and many businesses are not willing to invest the money in training and documentation.
There are also specific demands that require original code that a framework is not ideal for. One of the employers that contacted me from HN was wanting me to write and maintain a Jabber based chat client that runs the browser with high concurrency like a high volume IRC room. Performance was critical and so they didn't want to deal with the overhead of a large framework.
Also, large frameworks are generally there to supplement developers' insecurity with the DOM and general architecture in the browser. That doesn't solve for writing a Node.js application.
As for myself I do both client-side and Node.js work. I enjoy working with Node more because that space is less opinionated. Developers' have all kinds of irrational opinions that they are willing to bet their careers on when it comes to working in the browser. Compared to most of that foolishness I am a 10x developer, and its not because I'm great at writing software.
What is super frustrating though is talking through these concerns during a job interview and dazzling the interviewers virtually ensuring my selection for the position. This is super frustrating because it isn't my intent. I am not trying to impress anybody when I go down that risky path of laying all my cards on the table. I am trying to voice my concerns as directly as possible to ward off a future bad relationship. Then once I get hired and go to work on the team sure enough all my apprehensions that I attempted to illuminate during the interviews are present ensuring that everyday at work will be a slow death trying to sprint though an ocean of tar.