In short there are many variables at play, but without any context generally I’d recommend trying many small instances first. Now depending on your hardware, scale and application things may easily change in favor of big iron.
Sadly at the time there was a big perf problem with indexingdocuments with 20kb+ binary blobs (non-indexed field) and so the change to 2 nodes vs one did have little noticeable effect on the throughput benchmarks I did with our data back then (~2015 ES 1.4) In the end I dropped this split and focused on the other bigger problems.
Would love to revisit this exercise with more of free time and better tools.