People frequently seem to think this is about the line number it's on (666), but that doesn't have anything to do with it. That line number is a totally modern construction; the original source code was on punch cards. That particular comment was punched onto card number 0562 in the LUNAR LANDING GUIDANCE EQUATIONS log section. The original developers only referred to code by punch card number, and page number in the listing. So it really is just a coincidence, and the "NUMERO MYSTERIOSO" is referring to whatever is in GAINBRAK,1.