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I'm using nextdns.io and no-script with firefox, it works quite smooth when you accumulate the settings. You can export/import the no-script settings and merge with meld to keep the setting in sync between your PCs and laptops

Also "Privacy Badger" which smartly block scripts by checking cross site cookie, preset whitelist and custom whitelist/blocklist

I have 15 whitelisted sites. I think it took negligible effort to add them, you whitelist a site once and it stays there from there on.

i find blacklisting sites that abuse JS works better for me than the whitelist approach