Comment by qwerty456127 | Hacker News Reader

Comment by qwerty456127 | Hacker News Reader

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> One single 50mg vaporized dose of 5-MeO-DMT — derived from venom secreted by the Bufo alvarius toad — often produces hallucinogenic, boundless experiences within one second of inhalation that can last from 7 to 90 minutes, and on average lasts 20 minutes.

Don't try this at home. This probably applies if you get the actual toad stuff because it can hardly be pure but with pure freebase 5-MeO-DMT (which is a great thing to have) anything above 20 mg is dangerous, 50 mg has chances to be lethal.

I have tried about 15 mg (of pure freebase) and it actually had a profound effect. Not only it has "spiritual" sort of effects by giving you a direct experience of non-duality and perfect bliss, it also acts sort of like an awesome antidepressant - try it once and you then feel so much better (and concentration and awareness become so much easier, and anxiety is gone) for weeks after that.

I also microdose every time when I have hard time falling asleep - not only it relieves stress which prevents you from falling asleep, it also makes sleep much more refreshing and satisfying so the fact you didn't have much time to sleep doesn't hurt much any more.

50mg of 5-Meo-DMT is an absolutely terrible idea.

I'd need a citation, or even an anecdote, to believe that it could be lethal.

I've found a datasheet[0] that lists an intraperitoneal LD50 of 115 mg/kg in mice. That's more in keeping with my understanding.

[0]: https://www.caymanchem.com/msdss/11628m.pdf

> 50mg of 5-Meo-DMT is an absolutely terrible idea.

That's what I say.

> I'd need a citation, or even an anecdote, to believe that it could be lethal.

Somewhere on Reddit or on actualized.org (the place I've learnt about the substance from in the first place). 20 mg also is the highest dose Psychonautwiki mentions as heavy (which suggests nobody should ever try more). Doses directly above that are not straight lethal but, as far as I know, increase chances of getting a heart attack or stopping breathing to dangerous levels (theoretically, my personal experience doesn't actually include even a minor discomfort or disturbance in the heart rate or respiration despite my heart is very prone to rhythm issues). I would love to try a really heroic dose for sake of having an ultimate transcendence experience but wouldn't do that without supervision of a doctor.

Psychonautwiki also mentions the toad venom contains about 10% (15% max) of 5-MeO-DMT so 50 mg of the toad venom corresponds to just 5 mg of pure freebase (which is a toy dose). And it also contains 5-HO-DMT (bufotenin) and 5-MeO-NMT which certainly add their flavour to the experience making it different from pure 5-Meo-DMT.

Psychedelics as a sleep aid? You must have a very quiet mind. I can't sleep after a single bowl of weed.

It usually is impossible to fall asleep when a psychedelic is active but as soon as it wears off and all what's left is "afterglow" it usually is easy. 5-MeO-DMT comes up and wears off very quickly (much faster than LSD): 10-30 minutes for a real dose, just some minutes for a small dose. And the effect of 5-MeO-DMT is such a bliss it is natural to slide down right into a dream then (although you don't have to, you won't feel sleepy and fall asleep without a conscious intention).

As for the weed - you just need a strain adequate to what you want of it. If you want a sleep aid look for a CBD-rich and THC-low Indica strain (or just a CBD-only strain - these even are legal in many countries where normal weed isn't). There is a huge selection of weed strains that feel very different. There are strains good for work (energy and concentration), for creativity and thinking, for having fun, for sleeping and for other kinds of activities. I'm sure there is a strain that will shoot you dead-asleep instantly.

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