For-profit conference people that made money running cannabis conferences have started running psychedelic investment conferences but I have been told by those on the circuit that they are bullshit money grabs and that you should not attend. Two years from now they'll probably be real and still run by the same bullshit artists as today.

You could invest in quasi-legal grow ops in areas where mushrooms have been mostly decriminalized, like Oakland, California. You could invest in the largest marijuana companies that are the most likely to pivot to other plant medicines.

But, otherwise, basically, no, there is no reasonable way to invest in psychedelic mushrooms right now. Possibly buying domain names.

Something I did predicting the future of this industry was buy buylsd.com 5 years ago for $1500 (not operating now obviously until that's legal but another ten years would be a long time, I think). www.buymushrooms.com will similarly go up enormously in value in a future with widely legal drugs, at least as long as that is still a future with .com type in traffic and prioritized search engine rankings. I don't own buymushrooms.com but that would probably be a great investment at $10k, questionable at over $100k.