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At least for Alzheimer's there has been some hopeful advances recently[0]. Given the state of the low research funding allocated for it (especially compared to the disease's prevalence), that's pretty good progress I would say (and hopefully enough to spur more investment into solving it).

[0]: https://www.alzforum.org/news/research-news/2019-year-hope-a...

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You'll be happy to hear that, in recent years, the funding for Alzheimer's disease has boomed. My lab does a lot of research in AD and it is probably the fastest growing area of funding by NIH, from 600 million in 2015 to 2 billion this year[0]. Also, note Aging is another real growth area and a lot of Aging programs have AD/Dementia as a sub-focus. [0]: https://report.nih.gov/categorical_spending.aspx.

[Edit] from 1B to 4B if you count subcategories. Expect good things in the future.

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