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Comment by chrisco255 | Hacker News Reader

Not all of these are new drugs. NMN, for example, is a supplement that you can buy now. It's a bit expensive but the price is dropping as it becomes more popular.

Others mentioned include HGH, which has been around for decades. Only problem there is that it's a controlled substance so getting a prescription for anti-aging purposes may be difficult.

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I am not saying there isn't a use case for HGH, but you can increase your own natural HGH production through intermittent fasting, l-glutamine, and cycling up/down a few other molecules. I learned this by mistake, from trying to repair damage to my gut. The weird side effect was quite a bit of muscle development and I don't even work out. On top of that, I dampen mtorc1 with Berberine, Sulforaphane, Myrosinase, TransResveratrol, DIM+Quercertin and that should slow HGH production, but has the opposite effect and increases it.

And I second the NMN being expensive. I use about 800mg a day and it is by far the most expensive thing I take.

It would be great if someone out there could build a simple site to track cheap quality sources of NMN and the progress of price decline over time!

Just saw this after googling NMN supplement. https://www.scientificamerican.com/article/cancer-research-p...

I could really use that weird side effect. What other molecules did you cycle up/down?

I owe HN community a blog update on this process and I promise I will do that in the coming couple weeks. I've been a bit busy as of late. When I do, I will add it to my profile. It's not quite as simple as what to take, but also when to take, in what combinations and why. And it probably isn't the most scientific process, so I'm sure I will catch some flak for it.

It might be worth posting to reddit.com/r/longevity as well. I'm looking forward to it.

HGH is a wonder drug, but it's tricky. Not only for the expense factor, but like everything else, when you add exogenous hormones, your body stops producing them.

So if you supplement with HGH for years or even months, your body stops making it and the ability to produce more may take a very long time to come back. It may never come back.

Also, there are many types of tumors that have HGH receptors, and HGH has an even bigger impact on the tumor than it does on the rest of your body. So you're basically supercharging your cancer.

Probably worth cycling it then but no one is sure of optimal schedules even for fasting, let alone this...

Yes the tumors part was always what scared me about it and why i would not do it again. Its the first time i hear about hgh being able to stop your own production its not something ive found researching the downsides. Its Well know for steroids though.

I don't care how young HGH will make me feel if I'm sacrificing longevity because of increased cancer risk. Cancer is the #1 enemy of longevity.

Hgh works wonders used it for about 3 months and got sixpack doing hardly any workout. Lost all excess fat. Got a better sleeping pattern. Its easy to get your hands on online. Problem is that its mad expensive even more so with a prescription as the stuff without you might get was stolen or a cheaper brand.

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