37signals office is similar to left-brain: ordered, clean, and structured.
Zappos office is right-brain oriented: a bunch of spontaneous stuff everywhere.
What this actually means is that Zappos overload and "shutdown" right brain, making left brain talk to people (verbal communication is the left brain's job).
37signals overload the left brain, making right brain hack software and come up with out-of-the-box solutions to problems.