These approaches focus on cardiovascular system and general cell renewal, but I guess there are just a few more steps until immortality.
To the joint problems you are mentioning: we are already replacing various joints and bone parts in the body. The solutions aren't perfect though, there are risks of infection, death by septic shock, people often have pains, etc.
So if we can address cellular aging mechanisms, I think we'll have the latitude to address some of the more macroscopic aging problems (like joints, etc) through surgery.