Just to make sure I understand you correctly: you don't believe there exist any drugs which can permanently alter the psyche of an individual, up to and including psychosis?
There are definitely neurotoxic substances that can induce psychosis or other problems (such as parkinsonianism) but these tend not to be very usable either clinically or recreationally. I think overall, the chance of cardiotoxic or repository depression is more of a common problem with most common recreatioal drugs at common doses.