No it isn't a valid concern. For an equivalent distance, commercial flights are still safer than even the safest drivers. At 30000 feet you don't have to worry about some other drunk driver running a red light.
From https://www.google.com/amp/s/fortune.com/2017/07/20/are-airp...
For vehicles, “1.13 fatalities per 100 million vehicle miles traveled”
and
“Airline accidents per one million miles flown came in at a rate of 0.0035.”
So with an equal denominator, 0.35 vs 1.13. So if you're in the top 20% of safest drivers, which is not hard to reach considering all the idiots out there, you are safer driving.