I use Reason every day, and while I assure that its design was somewhat appealing at first, the sheer insanity of having to deal with virtual instruments and sequencers as if they were the "real thing" grows tiring extremely quickly.

Even during my education, wherein I dealt with more than a few individuals in Reason's "target market" (see: aging film composers who have spent their fair share of time plugging real cables into real sequencers) found it appalling and difficult to use.

The only reason I still use the program at all is because it has a few excellent patches built into it. The fact that I have to wade through the swamp of illogic that is its user interface remains one of most frustrating parts of my job as a media composer.