This is directly transferable to road driving. For example when switching sides of the road: going from France to UK, and suddenly it requires immense cognitive load to adapt to drive on left side (unless previous experience). Or different road standards, for example in Italy highway on-ramps are like 50 meters long (and road switches from 30-50 to 80-120 kph), which most people are unprepared to.
So while yes, GPS might take away some, but it's very nice to have under high cognitive load.