That's food, sundries, and information, the 3 main things that humans go out of their home to get, and before those 3 inventions you had to get into your community to get them.
Refrigeration allowed the growth of larger, depersonalized grocery stores.
Department stores were the first iteration of buying sundries at a place run by people you don't know.
Radio was the first non-local information source available on demand.
For most of human history, people lived in communities and had to interact with each other to live their lives. In the last 100 years out of 10,000 we suddenly don't anymore, and we're still figuring it out. And that's before you consider the impact of the Internet.
This has been a long, slow burn, and I worry that humanity won't be able to grow up fast enough to figure it out before we do something really stupid.