On my laptop, I use Apple's Mail.app, rather than a browser.
When I switch to my phone, also using the iOS Mail application, it's all synced up.
I seldom need to log in: the Mail apps use my keychain to sign me in to all the accounts transparently.
I have at least one signature for each account, and several for some. When sending a new email, I select the correct source address (two taps/clicks), and signature (another two clicks) if the default isn't correct.
Replies set the account automatically, so I just need to choose the signature there.