Using glitches can help you "sequence break", to a certain extent - if you use a glitch called "fake flippers", you can reach certain areas of LttP that would normally require the flippers without having them. You'll never be required to do so to beat a seed in default mode, but doing so can save a ton of time if there's a required item blocked by the flippers and the flippers are a pain to get.
The LttP randomizer also includes "glitches required" modes, where varying levels of glitch execution might be required to complete the game, and the logic is relaxed accordingly.
https://www.youtube.com/watch?v=vGIDzGvsrV8
Sounds like a good opportunity to dust off those graph algorithms many of us learned in undergrad CS.
They are aware of the items that are required to progress and make sure they are available appropriately.